LOW EGFL7 EXPRESSION IS ASSOCIATED WITH HIGH LYMPH NODE SPREAD AND INVASION OF LYMPHATIC VESSELS IN COLORECTAL CANCER

Low EGFL7 expression is associated with high lymph node spread and invasion of lymphatic vessels in colorectal cancer

Abstract Studies indicate EGFL7 as an important gene in controlling angiogenesis and cancer growth, including in colorectal cancer (CRC).Anti-EGFL7 agents are being explored, yet without promising results.Therefore, the role of EGFL7 in CRC carcinogenesis should be investigated.This study aimed to evaluate the prognostic value of EGFL7 expression i

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Predesigned chimeric deep inferior epigastric perforator and inguinal lymph node flap for combined breast and lymphedema reconstruction: A comprehensive algorithmic approach

Summary: The combined use of a deep inferior female-chastity epigastric perforator (DIEP) flap coupled with vascularized inguinal lymph nodes (VILNs) for simultaneous breast and lymphedema reconstruction has already been well established, and promising results have been reported.However, a standardized approach for the planning and shaping of this

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Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins

Abstract Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen.PD is categorized as a metabolic disease, but also as an inborn error of immunity.PD presents with

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